The former off-spinner has submitted his resignation to the Chairman Pakistan Cricket Board (PCB) Ramiz Raja.
Earlier, Saqlain Mushtaq had resigned from the post of interim coach of the national team.
PCB Chairman Ramiz Raja had hinted that a foreigner would be hired as the next head coach of the Pakistan cricket team.
Saqlain Mushtaq joined PCB in 2020.
Saqlain is regarded as one of the best spin bowlers in the history of cricket, he is best known for pioneering the “doosra”, a leg break delivery bowled with an off-break action.
He was the fastest to reach the milestones of 200 and 250 wickets in the ODI.